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Rana, A. C.
- Antioxidant and Adaptogenic Effect of an Herbal Preparation, Triphala
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Journal of Natural Remedies, Vol 8, No 1 (2008), Pagination: 82-88Abstract
Objective: To investigate the antioxidant and adaptogenic activities of Triphala, an Indian Ayurvedic medicinal preparation. Materials and Methods: Antioxidant activity of Triphala was determined by hydroxyl and nitric oxide radical scavenging methods. Adaptogenic activity was studied using swim endurance, anoxic stress tolerance and chronic stress induced behavioral despair test models. Triphala was administered at the dosage levels of 100 to 500 mg/kg b.w.p.o. Results and Discussion: Triphala was found to scavenge hydroxyl and nitric oxide radicals in vitro. The IC50 value for hydroxyl radical scavenging was 40.5 μg/mL and that for nitric oxide radical scavenging was found to be 40 μg/mL, respectively. Oral administration of Triphala formulation significantly improved the stress tolerance by increasing the swim duration (762.28 ± 7.17 minute), anoxic stress tolerance duration (39.11 ± 1.05 minute) and reduced the stress induced increase in the immobility period (61.11 ± 3.42 seconds) in chronic shock induced stress. Conclusion: Triphala has been found to be an excellent scavenger of hydroxyl radicals and nitric oxide radicals, whose excessive formation is implicated in oxidative stress. Triphala is capable of increasing the capacity to tolerate non-specific stress in experimental animals as evident from the restoration of parameters studied during different types of stress models.Keywords
Triphala, Antioxidant, Adaptogenic- Wound Healing Activity of Euphorbia neriifolia Leaf Ethanolic Extract in Rats
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Journal of Natural Remedies, Vol 7, No 1 (2007), Pagination: 94-101Abstract
Objective: Euphorbia neriifolia Linn. (Euphorbiaceae) is a commonly occurring plant around the dry, rocky, hilly areas of North, Central and South India. The milky latex and leaves of this plant is frequently used by the natives of Central India in case of burn, piles and to treat the deep cracks in soles of legs. The present study was designed to explore the wound healing activity of E. neriifolia leaf along with its effect on wound tissue growth and oxidative status. Methods: LD50 was determined following the OECD guideline No. 420 and 425. Wound healing activity was evaluated on excision wound and dead space wound model along with determination of hydroxyproline, protein, catalase and superoxide dismutase in wound granulation tissue. Results: E. neriifolia leaf extract in 200 & 400 mg/ kg doses showed significantly (p<0.05) enhanced epithelization. E. neriifolia at 200 and 400 mg/kg dose significantly (pp<0.001) increases hydroxyproline content, protein content, catalase activity and decreases superoxide dismutase activity in granulation tissue. The positive control groups were treated with vitamin C (250 mg/kg, i.p). Conclusions: E. neriifolia augments wound contraction and epithelisation. It also increased protein and hydroxyproline content, collagenation with added antioxidant activity on the wound site in 200 & 400 mg/kg doses. These activity may be due to presence of flavonoids and saponins which reduced oxidative stress in wound area and promote healing.Keywords
Euphorbia neriifolia, Wound Healing, Epithelization, Hydroxyproline, Antioxidant, Flavonoid- Synthesis of Some New 5-(4-(Phenylamino) Phenyl)-1, 3, 4-Thiadiazol-2- Amine Derivatives as Potent Antifungal Agents
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Authors
Anoop Singh
1,
A. C. Rana
2
Affiliations
1 Department of Pharmaceutical Chemistry, Bhupal Nobles College of Pharmacy, Udaipur (Rajasthan) 313001, IN
2 Rayat Institute of Pharmacy, Rail Majra, Ropar (Punjab), IN
1 Department of Pharmaceutical Chemistry, Bhupal Nobles College of Pharmacy, Udaipur (Rajasthan) 313001, IN
2 Rayat Institute of Pharmacy, Rail Majra, Ropar (Punjab), IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 2 (2011), Pagination: 221-226Abstract
Recently a series of 5-(4-(phenylamino)phenyl)-1,3,4-thiadiazol-2-amine derivatives were synthesized and their pharmacologically evaluated for antifungal activity. The purpose of this study was to evaluate the effects of the title compounds on fungal activity by varying the substituted in the1,3,4- thiadiazole moiety. All compounds of this series showed promising antifungal activity. It was found that some of these compounds possess marked antifungal properties comparable in efficiency to the reference drug Flukanazole. In present study the structures of compounds were confirmed by IR, UV <sup>1</sup>H NMR and elemental analysis.
Keywords
4-(Phenylamino) Benzoicacid, 5-(4-(Phenylamino)Phenyl)-1,3,4-Thiadiazol-2-amine Derivatives, Fungicide, C. albican, A. niger and IR, UV 1H NMR Spectroscopy.- Synthesis and Antimicrobial Activity of Some 3-Substituted-4H-1, 2, 4-Triazole Derivatives
Abstract Views :168 |
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Authors
Affiliations
1 B N Girls’ College of Pharmacy, Udaipur (Raj.), IN
2 Jodhpur Pharmacy College, Jodhpur (Raj.), IN
3 Rayat Bahara College of Pharmacy, Ropad Campus, Chandigarh, IN
4 B N College of Pharmacy, Udaipur (Raj.), IN
1 B N Girls’ College of Pharmacy, Udaipur (Raj.), IN
2 Jodhpur Pharmacy College, Jodhpur (Raj.), IN
3 Rayat Bahara College of Pharmacy, Ropad Campus, Chandigarh, IN
4 B N College of Pharmacy, Udaipur (Raj.), IN